MOSAIC: Intra-tumoral heterogeneity characterization through large-scale spatial and cell-resolved multi-omics profiling
We’re proud to share our latest publication — our large-scale, multi-center initiative mapping tumor complexity across thousands of cancer patients using spatial and single-cell omics, histology, and AI.
MOSAIC integrates:
- Spatial & single-cell transcriptomics
- Bulk RNA and exome sequencing
- H&E histology
- Curated, clinically-defined cohorts
We also introduce MOSAIC Window, a publicly available subset of 60 patients released via the EGA. Using four deeply profiled patients, we demonstrate how multi-omic analysis reveals intra-tumoral variability, uncovers cancer subpopulations with distinct drug sensitivities, and informs therapeutic recommendations.
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