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Transcriptome analysis of archived tumors by Visium, GeoMx DSP, and Chromium reveals patient heterogeneity

Benchmarking spatial omics platforms to understand tumor biology and guide technology selection for MOSAIC.
Benchmarking spatial omics platforms to understand tumor biology and guide technology selection for MOSAIC.
May 14, 2025

We are excited to share that our collaborative work with CHUV evaluating spatial omics methods for studying tumor biology is now published by Nature Communications!

We benchmarked Visium, Chromium, and GeoMx DSP for transcriptomic analysis of archived tumors from patients with breast cancer, non-small cell lung cancer, and Diffuse Large B-Cell Lymphoma (DLBCL)— revealing key insights into platform performance and tumor heterogeneity.

Our findings suggest that Visium and Chromium are better suited for high-throughput, exploratory projects, while GeoMx is a better fit for targeted studies.

This study played a key role in guiding technology selection for our ongoing MOSAIC research project.

Read the open access paper

About MOSAIC

MOSAIC is a large-scale initiative that combines patient samples and technologies from multiple institutions, hospitals and technology partners, who are joining forces with Owkin to create the largest multimodal, spatial omics atlas in cancer.

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